13 years from vague idea to pre-print!
Back in 2007, when we first had started to understand that fructose-1,6-biphosphate (FBP) is a glycolytic flux signaling metabolite, I had heard a talk from Christina Smolke suggesting that one can build RNA-based sensors for metabolites, and I thought that it would be cool to have such a sensor for FBP because we then could visualize glycolytic flux in single cells. A few years later I finally had the funding, and +5 years later, we have the sensor. This was a cool collaboration between different labs and a truly heroic effort from Alvaro and Vakil! Now, the final point is to get this published. I hope this will not take another 5 years … If you don’t want to wait (so long), here it is: https://www.biorxiv.org/content/10.1101/2020.10.11.335109v1